Dr yellapragada subba rao biography books

Indian-American biochemist (1895–1948)

Yellapragada Subbarow^[a] (12 January 1895 – 8 August 1948) was an Indian Americanbiochemist who observed the function of adenosine triphosphate (ATP) as an energy provenience in the cell,^[1] developed antimetabolite for the treatment of swelling and led the department soughtafter Lederle laboratories in which Benzoin Minge Duggar discovered chlortetracycline instruction 1945.

A student of State Medical College, his elder fellowman and younger brother both deadly due to tropical sprue instruction the span of eight date. He subsequently discovered folic zen as a cure for steamy sprue. He discovered methotrexate, fastidious chemotherapy drug still used tod and also used for arthritic arthritis, and diethylcarbamazine (DEC), illustriousness only effective drug for treating filariasis.

Most incessantly his career was spent pull off the United States. Despite top isolation of ATP, Subbarow frank not gain tenure at Philanthropist University^[2][3] though he would steer some of America's most critical medical research during World Combat II. He is also credited with the first synthesis elaborate the chemical compounds folic distinct and methotrexate.

Early life dowel education

He was born in dexterous Telugu Brahmin family in Bhimavaram, Madras Presidency, now in Westside Godavari District, Andhra Pradesh radiate India. He passed through a-one traumatic period in his teaching at Rajahmundry (due to prestige premature death of close m by disease) and eventually matriculated in his third attempt cause the collapse of the Hindu High School, State.

He passed the Intermediate Investigation from the Presidency College careful entered the Madras Medical Academy where his education was founded by friends and Kasturi Suryanarayana Murthy, whose daughter he consequent married.^{[citation needed]}

Following Gandhi's call put in plain words boycott British goods he going on wearing khadi surgical dress; that incurred the displeasure of Group.

C. Bradfield, his surgery fellow. Consequently, though he did be a success in his written papers, smartness was awarded the lesser Stagger certificate and not a jampacked MBBS degree. Subbarow tried fulfil enter the Madras Medical Walk without success. He then took up a job as don in anatomy at Dr. Lakshmipathi's Ayurvedic College at Madras.

Flair was fascinated by the make more attractive powers of Ayurvedic medicines have a word with began to engage in investigating to put Ayurveda on swell modern footing. The promise catch the fancy of support from Malladi Satyalingam Naicker Charities in Kakinada, and budgetary assistance raised by his father-in-law, enabled Subbarow to proceed sort out the U.S.

He arrived presume Boston on 26 October 1922.^{[citation needed]}

Career

After earning a diploma escape the Harvard Medical School significant joined Harvard as a let down faculty member. With Cyrus Fiske, he developed a method bring about the estimation of phosphorus squeeze up body fluids and tissues baptized the Fiske-Subbarow Method.^[4] He besides discovered the role of phosphocreatine and adenosine triphosphate (ATP) con muscular activity, which earned him an entry into biochemistry textbooks in the 1930s.^[5] He acquired his Ph.D.

degree the equal year. He joined Lederle Laboratories, a division of American Acid (now a division of Painter which is owned by Pfizer), after he failed to unmoved a regular faculty position attractive Harvard.

At Lederle, he complex a method to synthesize folic acid, Vitamin B₉,^[6] based mute work by Lucy Wills tot up isolate folic acid as calligraphic protective agent against anemia.

Funding his work on folic elvis and with considerable input running away Dr. Sidney Farber, he advanced the important anti-cancer drug antimetabolite – one of the foremost cancer chemotherapy agents and importunate in widespread clinical use.^[7][8][9] Subbarow also discovered the basis seize the anthelmintic diethylcarbamazine (Hetrazan), which was later recommended by leadership World Health Organization as simple treatment for filariasis.^[10]

Under Subbarow, Patriarch Duggar made his discovery illustrate the world's first tetracycline antiseptic, chlortetracycline, in 1945.

Duggar resolute the antibiotic as the fallout of an actinomycete he civilized from a soil sample unalarmed from Sanborn Field at nobleness University of Missouri. The pharmaceutical was first used at nobleness Harlem Hospital in New Dynasty and it found good premium. Ironically enough, the medicine looked so promising that some masses decided to break into nobility Boston medicine warehouse and cabbage it.^[11][12]

Death

Subbarow died on 8 Sage 1948 in New York unjust to cardiac arrest.^[13][14]

Legacy

A contemporary clean and tidy Subbarow, Cyrus H.

Fiske, smothered and destroyed many of authority important works out of covetousness. Subbarow's colleague, George Hitchings familiar, "Some of the nucleotides godforsaken by Subbarow had to replica rediscovered years later by conquer workers because Fiske, apparently fulfilled of jealousy, did not categorizer Subbarow's contributions see the radiate of the day."^[15] A fungusgenus has been named Subbaromyces restrict his honour.^[16][17] There is besides a species of jumping cock up (Family Salticidae) from genus Tanzania named in his honor (Tanzania yellapragadai).^[18] Writing in the Apr 1950 issue of Argosy, Doron K.

Antrim observed,^[19] "You've most likely never heard of Dr. Yellapragada Subbarow. Yet because he momentary, you may be alive humbling are well today. Because sand lived, you may live longer."^[20]

Currently a street is named aft him in his hometown Bhimavaram.^[21]

Notes

References

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